A simple, precise and accurate Stability indicating reversed phase liquid chromatographic method was developed and validated for estimation of tablet formulation. The separation was achieved on The HPLC system (Shimadzu VP, Japan), consisted of a system controller (SCL-10AVP), on-line degasser (DGU-14A), & mixture of Buffer (pH 5.5): Methanol (30:70) was used as mobile phase with flow of 1.2 ml/min with UV detection at 254 nm. The method was successfully validated in accordance to ICH guidelines for accuracy, precision, specificity, ruggedness, robustness and linear in the concentration range 20-100 ppm.
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